IFN- -mediated negative feedback regulation of NKT-cell function by CD94/NKG2

IFN- –mediated negative feedback regulation of NKT-cell function by CD94/NKG2

Activation of invariant natural killer T (iNKT) cells with CD1d-restricted T-cell receptor (TCR) ligands is a powerful means to modulate various immune responses. However, the iNKT-cell response is of limited duration and iNKT cells appear refractory to secondary stimulation. Here we show that the CD94/NKG2A inhibitory receptor plays a critical role in down-regulating iNKT-cell responses. Both ...

Negative feedback regulation of endothelial cell function by nitric oxide.

The objective of this study was to determine whether nitric oxide (NO) could function as a negative feedback modulator of endothelial cell function by inhibiting NO synthase in vascular endothelial cells. The rationale for this approach was a previous study from this laboratory, which revealed that NO inhibits neuronal NO synthase from rat cerebellum. In the present study, NO and NO-donor agent...

Dendritic Cells Negative Control of CD8 T Cell Priming by Type I IFN-Induced, NKT Cell-Mediated

Type I IFN-induced, NKT cell-mediated negative control of CD8 T cell priming by dendritic cells.

We investigated the negative effect of type I IFN (IFN-I) on the priming of specific CD8 T cell immunity. Priming of murine CD8 T cells is down-modulated if Ag is codelivered with IFN-I-inducing polyinosinic:polycytidylic acid (pI/C) that induces (NK cell- and T/B cell-independent) acute changes in the composition and surface phenotype of dendritic cells (DC). In wild-type but not IFN-I recepto...

Negative Feedback Regulation of IFN-; Pathway by IFN Regulatory Factor 2 in Esophageal Cancers

IFN-; is an antitumor cytokine that inhibits cell proliferation and induces apoptosis after engagement with the IFN-; receptors (IFNGR) expressed on target cells, whereas IFN regulatory factor 2 (IRF-2) is able to block the effects of IFN-; by repressing transcription of IFN-;–induced genes. Thus far, few studies have explored the influences of IFN-; on human esophageal cancer cells. In the pre...